Nonstandard abbreviations: GABA: γ-aminobutyric acid TM: transmembrane domain Amil: amiloride ASIC: acid-sensing ion channel GMQ: 2-guanidine-4-methylquinazoline EGTA: ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid HEPES: 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid TEA-Cl: tetraethylammonium chloride DMSO: dimethylsulfoxide GLIC: Gloeobacter violaceus pentameric ligand-gated ion channel PAM: positive allosteric modulation

نویسندگان

  • Heather D. Snell
  • Eric B. Gonzales
چکیده

Amil: amiloride ASIC: acid-sensing ion channel GMQ: 2-guanidine-4-methylquinazoline EGTA: ethylene

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Amiloride and GMQ Allosteric Modulation of the GABA-A r1 Receptor: Influences of the Intersubunit Site s

Amiloride, a diuretic used in the treatment of hypertension and congestive heart failure, and 2-guanidine-4-methylquinazoline (GMQ) are guanidine compounds that modulate acid-sensing ion channels. Both compounds have demonstrated affinity for a variety of membrane proteins, including members of the Cysloop family of ligand-gated ion channels, such as the heteromeric GABA-A abg receptors. The ac...

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Amiloride, a diuretic used in the treatment of hypertension and congestive heart failure, and 2-guanidine-4-methylquinazoline (GMQ) are guanidine compounds that modulate acid-sensing ion channels. Both compounds have demonstrated affinity for a variety of membrane proteins, including members of the Cysloop family of ligand-gated ion channels, such as the heteromeric GABA-A abg receptors. The ac...

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تاریخ انتشار 2015